《癌癥發現》發表了影響深遠的同行評議文章，描述了研究和臨床試驗的主要進展。作為首要的癌癥信息資源，該雜志還向讀者提供評論文章、觀點和評論、新聞報道和研究觀察重要期刊文章的摘要，以使他們了解該領域的最新發現。課題涵蓋了癌癥研究和醫學的各個領域，從實驗室到臨床和流行病學研究。

Cancer Discovery publishes high-impact, peer-reviewed articles describing major advances in research and clinical trials. As the premier cancer information resource, the Journal also presents Review Articles, Perspectives and Commentaries, News stories, and Research Watch summaries of important journal articles to its readers to keep them informed about the latest findings in the field. Topics span the spectrum of cancer research and medicine from the laboratory to the clinic and epidemiologic studies.