一般和比較內分泌學是專門從事基礎內分泌研究。該雜志強調基礎研究，偶爾也會對某個特定領域或問題進行簡要的評論。該雜志根據編輯的意見為每篇文章提供一個免費的彩色版。研究領域包括:激素作用的細胞機制;脊椎動物和無脊椎動物內分泌系統的功能、發育和進化方面;神經內分泌學;生殖生物學。

General and Comparative Endocrinology is devoted to basic endocrinological research. Emphasizing fundamental research, the journal also features occasional brief reviews that deal with a particular field or problem. The journal offers one free color plate per article at the discretion of the editors. Research Areas include: Cellular mechanisms of hormone action; Functional, developmental, and evolutionary aspects of vertebrate and invertebrate endocrine systems; Neuroendocrinology; Reproductive biology.